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"However, we still have a long way to go in building a health care system that provides comprehensive care, coverage and payment of such care for people with obesity that is free of weight bias." Self-pay patients with obesity now have additional Zepbound vial options, including 2.5 mg, 5 mg, 7.5 mg and 10 mg doses

Cost-effectiveness analysis A 2025 cost-effectiveness study published in PubMed found that tirzepatide was dominant over liraglutide from a UK healthcare perspective, meaning it produced both better outcomes and lower costs

Aim for 75-100 grams daily

Coverage rules, prior authorization, and step therapy rules consider each drug separately