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Role of altered metabolism of triglyceride-rich lipoprotein particles in the development of vascular dysfunction in systemic lupus erythematosus
The in vitro cell line assessment of the nanoparticles in the U87 cells showed a strong anti-proliferative effect with only 10% cell survival and around threefold increase in miR-137 levels
However, glutathione supplementation or an imbalance in its levels may have unintended consequences
DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45
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