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32, 33 This hypothesis is supported by observations that the first-degree relatives of Crohns disease (CD) patients are at increased risk of developing IBD and some of these relatives also demonstrate mucosal leakiness

Whereas CD5 and IL-2 influence immune system functions and MMP2 is important in maintaining the extracellular matrix in skin, tendons and other connective tissue, and Tram1 increases protein production

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It was unexpected that the mice subjected to the transient increase in gut permeability were resistant to colitis induced by the administration of trinitrobenzene sulfonic acid