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A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]

Researchers who prefer simplicity can use 10mg vials with 1mL reconstitution throughout the first 8-12 weeks (covering doses from 2mg through 8mg within a single draw), then switch to 20mg vials with 1mL reconstitution for the 8mg and 12mg maintenance phases

These side effects are transient and typically subside within a day or two following injection

Lab follow-up helps show whether the schedule is correcting deficiency and whether ongoing maintenance is needed