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In addition to these cellular components, the tumor microenvironment also includes non-cellular elements such as the extracellular matrix (ECM) and soluble factors such as chemokines, cytokines, growth factors and extracellular vesicles, all of which play a key role in tumor development and progression ( Fibroblasts contribute to tumor progression by secreting extracellular matrix components, growth factors and cytokines that promote tumor cell invasion, angiogenesis and immune modulation ( Tumor-associated immune cells can generally be classified into two categories: tumor-antagonistic immune cells and tumor-promoting immune cells

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Ferroptosis: a double-edged sword mediating immune tolerance of cancer