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However, the total population of these states with conformations close to Cys13 (distances below 0.5 nm) is in the range of 5.4 % ( 7a ) 6.2 % ( 7b ), 8.3 % ( 7c ) and 14.1 % ( 7d ) to 0.5 % ( 7i ) and 0.2 % ( 7f ) (Table S2), indicating that further compound optimization is still necessary and possible to further increase the reactivity

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