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When to continue, when to adjust, and when to stop The decision to push through skin sensitivity versus modifying your protocol versus stopping entirely depends on several factors

Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)

however, variations in concentration ranges, exposure times, delivery methods, and oxidative stress inducers influence effect sizes and statistical power

This scattered evidence makes it extremely challenging for clinicians to dictate which pharmacologic strategy offers superior metabolic benefits