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Upon activation, TLR4 signals through MyD88-dependent pathways to induce NF-B nuclear translocation, leading to transcription of pro-inflammatory cytokines (e.g., IL-6, TNF-) and enzymes involved in iron metabolism and lipid peroxidation, both key components of ferroptosis ( Figure 1 ) (86)

Molecules 25(7):1719 Ameen M, Zafar A, Mahmood A, Zia MA, Kamran K, Javaid MM et al (2024) Melatonin as a master regulatory hormone for genetic responses to biotic and abiotic stresses in model plant Arabidopsis thaliana : a comprehensive review

Accessed October 11, 2020

High-density lipoprotein (HDL)-cholesterol concentrations were mildly increased and triglyceride concentrations were not affected by garlic supplementation