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Platelet-derived growth factor-BB (PDGF-BB), upon binding to its receptor PDGF receptor- (PDGFR), triggers receptor dimerization, autophosphorylation, and activation [39]
Semaglutide works primarily on the GLP-1 receptor, while tirzepatide activates both GLP-1 and GIP receptors, creating potential synergy when used together
Change history 2/27/2024 A Correction to this paper has been published: 10.1038/s41591-024-02883-1 Extended data is available for this paper at 10.1038/s41591-023-02597-w
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