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For example, the TRPA1-specific agonist cinnamaldehyde significantly inhibits ferroptosis in cellular and animal models by activating CaMKII phosphorylation and Nrf2 nuclear translocation [87]

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However, achieving and maintaining substantial weight loss through diet and lifestyle is challenging, and acetazolamide often provides only partial headache relief while causing dose-limiting side effects such as paresthesia, fatigue, nausea and cognitive impairment