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Description

Inorganic riboswitches thus far described are known to sense transition metal ions, 226,228,600602 fluoride anion 603 and other ions including the alkali metals Li I and Na I , and the alkaline earth metals Mg II and Ca II (Figure 22A)

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Other discontinuation criteria may include severe adverse events (AEs) that cannot be managed by dose reductions or pausing the medication, a lack of impact on hyperphagia after 12 months of treatment, or significant issues with nonadherence