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Patients can expect to lose 10-15% of their body weight (up to 17.4%) over approximately 68 weeks

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In addition, HDACi promotes the degradation of ECM by regulating the activity of matrix metalloproteinases (MMPs), thereby attenuating the interaction between tumor cells and the stroma and further inhibiting tumor metastasis ( 2.2 Effect of HDACi on macrophages The role of HDACi in regulating the tumor microenvironment is receiving increasing attention, particularly its impact on tumor-associated macrophages

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