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They both lower the risk for heart-related complications, but differ in other approved uses and populations, side effects, dosage forms and costs

Semaglutide withdrawal also commonly involves a return of heightened appetite and food cravings

They found that the cost of tirzepatide was about $197,000 per additional quality adjusted life year (QALY), and the cost of semaglutide was about $468,000 per QALY