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began to take GLP-1 drugs, total spending could reach $411 billion

Eligible participants were those with either a BMI 30 kg/m 2 , or 27 kg/m 2 plus one or more of the following: hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease

Research from National Library of Medicine in 2024 also suggests GLP-1 drugs are linked to adverse gastrointestinal events, including nausea, vomiting, delayed gastric emptying and pancreatitis

NET-associated alarmins such as S100A8/A9 stimulate TLR4-mediated NLRP3 inflammasome activation, amplifying IL-1/IL-18 production and contributing to myocardial fibrosis