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doi: 10.3390/toxics11030223 5

The effect of AEF0117 at six doses (0, 0.5, 1.5, 15, 30 and 50 g kg 1 ) was tested on the impairment in PPI induced by THC (10 mg kg 1 , i.p.) and compared to vehicle in C57BL/6N male mice (9 weeks old)

Recent research surprisingly demonstrated that serotonin-secreting enterochromaffin cells were the major chemical sensors for vagal afferent neurons in the proximal duodenum, whereas Glp1r -expressing ND neurons predominantly innervated muscle layers of the stomach and responded to stretch rather than to chemical stimuli entering the duodenum 46

Severe pain that does not improve with OTC treatments