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Krug I, et al

They can reduce oxidative stress, show anti-inflammatory and anti-tumorigenic properties, alter glycemic control and lipid metabolism, and alter the release of inflammatory cytokines and chemokines (20, 21)

(This is really useful because, if you find effectiveness with a lower dose of saw palmetto, then you can make Horbach an even better value)

Some patients and conditions might use lower doses (e.g., 100-300 mg IV) especially if the goal is general antioxidant support or if higher doses are not tolerated, but evidence is strongest for the 600 mg IV regimen in neuropathy