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wustl.edu Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins As a physician-scientist, David Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage

The developed models were used to investigate the initial dose for pediatric patients (2 of 30), the potential for DDIs caused by delayed gastric emptying (2 of 30), and the pharmacokinetics of once-monthly dosing (1 of 30) (Table 6)

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Int J Mol Sci 20(13):3328 Griffith OW, Stuehr DJ (1995) Nitric oxide synthases: properties and catalytic mechanism