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Research in Cell Reports has shown that glucagon receptor signaling promotes thermogenic gene expression in fat tissue (Habegger et al., 2013) Reduced hepatic lipid accumulation By promoting fat breakdown in the liver, glucagon receptor activation helps reduce liver fat content a finding observed in retatrutide clinical trials The addition of glucagon receptor activation means retatrutide does not rely solely on appetite suppression and reduced caloric intake

Dehydration and reduced oral intake commonly occur with GLP-1 receptor agonists due to their effects on appetite suppression and gastrointestinal motility

Sobocki J, Herman RM, Fraczek M

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