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(NCT04111133) Disclosures: Madhumita Premkumar: Nothing to Disclose, Kamal Kajal: Nothing to Disclose, Manhal Izzy: Mallinckrodt: Speaking and Teaching, Vishesh Kumar: Nothing to Disclose, Bhupendra Sihag: Nothing to Disclose, Ajay Bahl: Nothing to Disclose, Ankur Gupta: Nothing to Disclose, Ajay Duseja: Nothing to Disclose, Ashwani Sood: Nothing to Disclose, Deepy Z: Nothing to Disclose, Rohit Mehtani: Nothing to Disclose 488 CHANGES IN HEPATITIS C VIRUS SCREENING AND TREATMENT RATES IN PREGNANT INDIVIDUALS BEFORE AND AFTER IMPLEMENTATION OF UNIVERSAL SCREENING GUIDELINES Chandler Shapiro 1 Sheena Gillani 1 Nancy Reau 1 Samantha de los Reyes 1 , 1 Rush University Medical Center Background: Hepatitis C virus (HCV) incidence has doubled since 2013 due to injection drug use among those of reproductive age, leading to higher rates of HCV during pregnancy