glp 1 cv benefit It might be the era of GLP-1 RA, but insulin is still the resort when plan goes sideways GLP-1 Agonists: Using Semaglutide, Tirzepatide,

In the afternoon on the experimental day, semaglutide (Novo Nordisk) and GLP-1MK-801 were dissolved in isotonic saline at a concentration of 0.11 nmol l 1

Despite their effectiveness, GLP-1 therapies are not without limitations

Unlike semaglutide, which targets only GLP-1 receptors, tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

However, previous large-scale trials comparing intensive versus standard glycemic control, such as ACCORD and ADVANCE, demonstrated that while intensive glucose lowering modestly reduced the incidence of nonfatal MI, it did not significantly reduce CV mortality among patients with T2D (70, 72, 73)