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After treatment initiation, minimum heart rate increased by ~1.1 bpm and nighttime HRV (RMSSD) dropped by ~1.8 ms signs of increased physiological load and reduced parasympathetic recovery during sleep

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Special Warnings and Important Precautions 9.1 Risk of Renal Impairment and Electrolyte Disturbance The use of Olmesartan Medoxomil and Metoprolol Succinate requires vigilant monitoring of renal function, especially in patients with pre-existing kidney disorders or concurrent nephrotoxic medications

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The NAD+ salvage pathway can work more efficiently, boosting intracellular NAD+ levels

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