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Some medications, such as certain antipsychotics or corticosteroids, may counteract weight loss effects

Combined with mindful eating, exercise, adequate sleep, and avoiding sugary, ultra-processed foods, these strategies can help you maintain steady GLP-1 levels and support sustainable weight loss

However, human studies showed that improvements in pain are predominantly attributed to weight loss, rather than direct analgesic effects in the condition of osteoarthritis [47]

The most cutting edge weight-loss agents used in clinical practice are those which reduce food intake by modulating satiety neuropeptide activity like GLP-1 / GIP receptor agonists (semaglutide, tirzapetide amongst others)