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However, antigen sampling of luminal microbes is necessary for immunological development, bacterial clearance and the production of IgA, the latter of which is important in restricting microbial adhesion to the mucosal layer and coating commensal species to limit their interaction with immune system (Johansen et al

However, anecdotal reports from online forums cited in a 2025 systematic review included anxiety and panic attacks, depression and anhedonia, insomnia, heart palpitations, fatigue and weakness, and loss of appetite

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