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The logic is straightforward: build up tissue levels initially, then maintain them with less frequent dosing

From the proceedings, this conclusion was based on evidence that demonstrated: Statistically significant differences in diffusion tensor imaging-based fractional anisotropy between service members with documented mTBI associated with blast, and service members with impact-only mTBI

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It has been reported that macrophages may undergo pathological diffusion from blood vessels to the CNS during inflammation and transform into microglia cells, which promote the pathological development of intracranial nervous system diseases (Ramlackhansingh et al., 2011), which then continuously release a series of inflammatory mediators, leading to oxidative stress