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These medications activate GLP-1 receptors in the brain, which helps to reduce hunger as well as increase feelings of fullness after eating

The rhythmic release of GH secreted by the pituitary gland is controlled by growth hormone-releasing hormone and somatostatin in the hypothalamus ( Regulation of Circadian Clock System on the GH/IGF-1 Axis Human GH (hGH) transgenic mice were used to express the hGH gene in mouse pituitary somatotrophs (Vakili et al., 2016)