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Endogenous GHK-Cu concentrations in blood plasma are approximately 200ng/mL in young adults and decline significantly with age, which has driven research interest in its potential roles in tissue maintenance and repair

Patil S, Perry A, MacCollin M et al (2008) Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas

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It is synthesized in L-cells located in the intestinal mucosa, -cells found in the pancreatic islet, and neurons residing in the nucleus of the solitary tract