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To put this in perspective, if you inject 0.5 mg into your abdomen and roughly 0.445 mg reaches your bloodstream, injecting the same dose into your thigh might deliver roughly 0.392 mg

GPNMB expression was also increased in senescent human umbilical vein endothelial cells, in endothelial cells from old mice, and in several other tissues such as bone marrow and lungs 62 , suggesting that GPNMB could be a potential target in senescence-related pathological conditions

doi: 10.5530/pj.2018.1.32 23 RiyantiSSugandaAGSukandarEY

Improved mitochondrial function underlies the protective effect of Pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats