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Patients who attained SVR with interferon or interferon-ribavirin, much higher in infections with genotypes 2 and 3, would have been excluded from genotyping.34,40 However, the first two hypotheses could also be applied to genotype 1a and 4 infections, also associated with IDU, while the third hypothesis would have involved so few patients in our series that its relevance would be negligible

Err on the side of discarding medication that is both near expiration and has been temperature-stressed

Schneider, G., Kirschner, M

If you have elevated B12 and symptoms like fatigue, weight loss, or abdominal pain, the symptoms are likely from the underlying cause of the elevation , not from the B12 itself