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Not every patient wants or needs B12 in their tirzepatide

Some have even described them as a medicinal version of bariatric surgery. While these medications dont interfere with nutrient absorption the way surgery does, they do dramatically reduce appetite

On tolerability, retatrutide's GI adverse event rate is higher than tirzepatide's at matched mechanistic dose, which is the tradeoff for the additional mechanism

Whilst GLP-1 receptor agonists demonstrate favourable efficacy for weight loss, they are not suitable for everyone and carry potential adverse effects that require careful consideration and monitoring