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15 In the human population, the D 4 receptor is highly polymorphic with variants containing different length insertions in I3
2.6.3 Association mechanism between NADPH metabolic imbalance and ferroptosis Nicotinamide adenine dinucleotide phosphate (NADPH), is closely associated with the pathogenesis and progression of various metabolic diseases, and plays a pivotal role in ferroptosis regulation by modulating antioxidant system function and iron metabolism homeostasis, with its intracellular levels directly dictating cellular susceptibility to ferroptosis (145, 146)
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