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These gastrointestinal side effects typically improve within the first 2 months of treatment as physiological adaptation occurs. Expected Timeline: Weeks 1-4 : Peak intensity, especially after starting medication or dose increases Weeks 4-8 : Gradual improvement as the body adjusts to delayed gastric emptying Week 8+: 80% of cases show significant resolution Persistent cases : May require dose adjustments or alternative treatments Sulfur burps are normal on Wegovy and other GLP-1 medications as the digestive system adapts to slower gastric motility

Patients with end-stage renal disease were excluded from this analysis

Wegovy pens are single-dose and should be discarded immediately after injection, though unopened pens may be kept at temperatures up to 86F for up to 28 days prior to use

Compounded tirzepatide is not FDA-approved as a finished drug product