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Estrogen deprivation has been shown to be a critical mediator of impaired wound healing in both postmenopausal women and aged men, and topical estrogen application reverses age-associated delayed wound healing in both elderly men and women

References Chang, C.H., Tsai, W.C., Lin, M.S., Hsu, Y.H., Pang, J.H

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The flux of cysteine and the end products are driven by how much methionine is eaten, as well as how much glutathione is needed to combat oxidative stress in cells.[ref][ref] Homocysteine thiolactone: Damaging endothelial cells, increasing inflammation Homocysteine can also become homocysteine thiolactone when a thiol group is attached