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The dual-receptor mechanism of tirzepatide means it is doing things that semaglutide simply cannot do at any dose, so a true one-to-one equivalency does not exist
GI dysfunctions are a key non-motor symptom of PD, often appearing at a very early stage of the disease
Two estimands were employed: the trial product estimand, which evaluated treatment effects assuming perfect adherence to the assigned regimen, and the treatment policy estimand, which included all randomized participants regardless of adherence
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