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Further work aimed at developing longitudinal-based studies to assess whether there may be a bidirectional relationship between UPF and mental health disorders offers a new avenue for further translational research studies
Supplementary Information accompanies the paper on the Neuropsychopharmacology website ( Supplementary information Rights and permissions About this article Cite this article Lavoie, S., Murray, M., Deppen, P
Materials and Methods RAW264 Cells, GSH Depletion, and Treatment RAW264 cells were cultured in Roswell Park Memorial Institute medium 1640 with 2 mM l-glutamine (Sigma), 100 U/ml penicillin, 100 g/ml streptomycin sulfate (Invitrogen/Life Technologies), and 10% heat-inactivated FCS (Sigma)-omplete medium
Growth Factor Upregulation BPC-157 upregulates the expression of several growth factors and their receptors: VEGF (Vascular Endothelial Growth Factor) - promotes angiogenesis, the formation of new blood vessels at injury sites EGF receptor - involved in cell proliferation and differentiation NGF (Nerve Growth Factor) - relevant to its observed neuroprotective effects This growth factor cascade is likely the primary mechanism behind its observed effects on tissue repair
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