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In high concentrations, however, some amino acids can be toxic to certain cells, as observed with Glu toxicity in neurons [45] and Cys toxicity in many types of cells, including neurons and hepatocytes

This decline correlates directly with reduced collagen synthesis and visible signs of skin aging

In that sense, HRT appears to potentiate the effect of the most common anti-parkinsonian drug, levodopa, reducing its response threshold and enhancing its sensitivity (Tsang et al., 2000

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