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Cardiovascular risk markers also improved, including reductions in non-HDL cholesterol, triglycerides, C-reactive protein, and systolic blood pressure

In addition, PA ameliorates hepatic steatosis through several mechanisms

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Key findings (Vafaei et al., 2025): 30-50 mg/kg mirtazapine: dose-dependent seizure suppression Mediated by CB1/CB2 activation (proven by antagonist blockade) GABA-independent mechanism (distinct from benzodiazepines) Appetite/weight gain provides in-vivo functional validation of CB1 engagement The broader implication: Clinicians and researchers have been using ECS pharmacologyunknowinglyfor decades