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It may be that we should continue treatment in people who have had cardiovascular disease, even if they dont lose as much weight as we would like. This is already the case in the United States where, in March 2024, the US Food and Drug Administration approved Wegovy to treat adults with cardiovascular disease who also have obesity or are overweight but without diabetes mellitus

and for Boc-His(Boc)-OH.DCHA, the coupling is performed by using a HOAT + HATU + TMP system