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FIGURE 4 5.1.3 Regulation of autophagy in mammalian cells Multiple kinases are responsible for regulation of mammalian autophagy, among them, the mechanistic target of rapamycin (mTOR) and adenosine monophosphate (AMP)-activated protein kinase (AMPK) play important and antagonistic roles (Tamargo-Gmez and Mario, 2018)

Currently, no treatment has been established to stimulate nerve growth or reverse the underlying neuropathology, hence the urgent need to take steps in terms of mechanism-based therapies [7]

GLP-1 receptor agonists represent a promising class of medications with significant benefits for managing type 2 diabetes and obesity

Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells