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doi: 10.1084/jem.20171406 54 NationD

Product Specifications: Composition: Water for Injection, USP with 0.9% (9 mg/mL) Benzyl Alcohol, NF (bacteriostatic preservative) Volume: 30mL per sterile vial Container Type: Type I borosilicate glass vial with sterile rubber closure and aluminum overseal pH: 4.5 7.0 (per USP monograph) Osmolality: Hypotonic (approximately 0 mOsm/kg) Sterility Assurance Level: 10 (terminal steam sterilization) Bacterial Endotoxin: Bacterial Endotoxins Test Particulate Matter: Complies with USP Particulate Matter specifications FOR RESEARCH USE ONLY

Medication adjustments may be considered in consultation with prescribing clinicians: Dose reduction : Lowering the Ozempic dose may reduce symptom severity whilst maintaining some glycaemic benefit Slower titration : Increasing the dose more gradually than standard protocols may improve tolerability Prokinetic agents : In the UK, medications such as metoclopramide are generally restricted to short-term use (maximum 5 days) due to neurological side effect risks

03 Research Highlights Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade 04 Dosage Administration & Timing Oral administration (capsule or solution) or Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue