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Furthermore, using contrast variation, it was shown that the nucleosome unfolding induced by a decrease in ionic strength represents a complex process, where DNA became partially unfolded below the transition point, whereas only small conformational changes occur in the protein core (Uberbacher et al., 1983)

Conversely, the significant reduction in fissures with GABA treatment suggests that GABA may help mitigate these actual tissue stress

For further information on safer colchicine prescribing, see: bpac.org.nz/bpj/2014/september/safer-prescribing.aspx (published in 2014