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Side effects vary individually, and the reasons may be related to the high local concentration of metformin in the gastrointestinal tract and the gut microbiota

It is prioritized as a first- and second-line treatment option for patients with type 2 diabetes in major domestic and international clinical practice guidelines

When they administered semaglutide to lab animals, the c-Fos distribution indicated that a number of brain regions were being indirectly activated by the GLP-1R agonist that had not shown up as being directly activated (Gabery et al., 2020)

It is worth noting that older terminology such as "adult-onset diabetes" for type 2 or "juvenile-onset diabetes" for type 1 is not only outdated but also increasingly inaccurate