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NMO is mainly caused by auto-anti-AQP4 antibodies 282 that initially attack astrocytic endfeet, 283 leading to complement-mediated lysis and destruction of the glial limitans and astrocyte degeneration, which in turn cause the other pathophysiological sequalae (Fig

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Alarjani KM, Yehia HM, Badr AN, Ali HS, Al-Masoud AH, Alhaqbani SM, et al