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Although Minocycline inhibits microglial activation (Wu et al., 2002), other studies have shown it to significantly exacerbate MPTP-induced damage to DA neurons in vitro and in vivo (Yang et al., 2003)

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The absolute magnitude of this reduction was significantly less in heterozygous carriers of the p.S539W PAM allele with a mean change in HbA1c of -0.69% (-7.5 mmol/mol)