Activated neutrophils secrete myeloperoxidase (MPO), neutrophil elastase (NE), protease 3, histamine and matrix metalloproteinase 9 (MMP-9), all of which increase OxS, promote liver injury and the proliferation of hepatic stellate cells (HSCs), thereby increasing liver fibrosis 123,124
Furthermore, targeting glycolysis, a metabolic pathway heavily relied upon by melanoma for survival and proliferation, represents an encouraging therapeutic strategy to slow down melanoma growth and enhance antitumor efficacy
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These results, combined with our previous findings that FM IgG induces pain-like behaviour in mice, provide a possible answer to one mechanism of nociplastic pain in FM