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Because semaglutide is a protein-based molecule, if taken as a tablet, it would be broken down by digestive acids before it could reach your bloodstream and do its job

In one study, emotional eating dropped from 77.5% of participants before starting semaglutide to 11.5% after taking the medication

M.BauerA.FellenbergK.et al (2010)

For example, 5-HT engages HTR2A and HTR3A receptors on macrophages, enhancing prostaglandin E (PGE) expression and thereby influencing local immune responses (De Vadder et al., 2018)Indirectly, the ANS regulates gastrointestinal motility and mucus secretion, which alters the physical proximity and duration of bacterialimmune cell interactions, ultimately affecting immune activation