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In the current study, we conducted a systematic study and meta-analysis based on the previous findings to obtain a more accurate estimation of the correlation between the genes associated with the IGF pathway (IGF-1, IGF-2, IGFBP3, IGF1R and IRS1) and the risk of CRC and precancerous polyps

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8 Rheumatoid arthritis Shared inflammatory pathways similarly link periodontitis to autoimmune joint disease, yet in rheumatoid arthritis, the oral cavity assumes an even more provocative role, not merely amplifying inflammation, but potentially initiating autoimmunity itself