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Over time, pain can become a constant background signal

Studies show that people with rheumatoid arthritis and osteoarthritis often have altered gut microbiomes compared to healthy individuals

They stated this disparity will create a strong financial incentive to shift patient care to the more expensive HOPD setting, which could strain hospital capacity, create access issues for rural and underserved patients, and cause physician offices and mobile practices to shutter

Due to their unique biocompatibility, low immunogenicity and good cross-species transmission ability, they have become an emerging carrier to improve bioavailability (Feng et al., 2025