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After six months, about 25% of participants without the variants reached target HbA1c levels, compared with 11.5% of those with the p.S539W variant and 18.5% with the p.D563G variant

The following OGTT-based indexes for insulin sensitivity were calculated: OGIS index 77 , insulin sensitivity index 78 , the adipose tissue insulin resistance index 79 , muscle insulin sensitivity index 80 and hepatic insulin resistance index 81

Hepatocyte-specific PSAT1 knockout (KO) mice and wild type (WT) littermates were fed a high-fat control or SAAR diet

Argentyn 23 1/2 1 tsp daily Nystatin tabs or liquid 500,000 units 1/4 to 1/2 tsp or tab daily, increasing to 1 tsp or tab 4x/day (if gliotoxin or candida present) Itraconazole (Sporanox) 100mg every week or two, increasing to daily or even 1-2 tabs 2x/day Fluconazole (Diflucan) 100mg every week or two, increasing to daily or even 2x/day N-acetyl-cysteine 500mg 1-2 caps 2x/day (especially with Gliotoxins from Aspergillus or Candida) Special considerations Very sensitive or toxic patients may need pretreatment prior to using the above measures