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The Evidence Gap: What the Human Data Actually Shows This is where the essay has to be more direct than most of what you will read online

Consecutive nondefecation days was associated with the primary outcome, all-cause death, noncardiovascular death, and nonfatal ischemic stroke, and maximum daily defecation frequency was associated with the primary outcome, all-cause death, noncardiovascular death, cancer death, and heart failure hospitalization

We focus on the roles of the carnitine pool in energy metabolism, mitochondrial homeostasis, epigenetic regulation, inflammation and immune homeostasis, endocrine regulation, neuromodulation, and signal transduction