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However, side effects and costs are key to the high dropout rates

193 Another study also found that patients with higher baseline gut flora -diversity respond better to immunotherapy, and a machine learning classifier based on serum metabolites performed better (AUC 0.793) than a classifier based on gut flora in predicting potential beneficiaries of immunotherapy

For example, folic acid may interact with some drugs for seizures or parasitic infections, while taking vitamin E alongside certain blood thinners, weight-loss drugs, and bile acid sequestrants may cause adverse effects

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